View source for 5mpo


==Crystal structure of human molybdopterin synthase complex==
<StructureSection load='5mpo' size='340' side='right'caption='[[5mpo]], [[Resolution|resolution]] 2.43&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5mpo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MPO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.43&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mpo OCA], [https://pdbe.org/5mpo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mpo RCSB], [https://www.ebi.ac.uk/pdbsum/5mpo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mpo ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/MOC2A_HUMAN MOC2A_HUMAN] Sulfite oxidase deficiency due to molybdenum cofactor deficiency type B. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/MOC2A_HUMAN MOC2A_HUMAN] Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.[HAMAP-Rule:MF_03051]<ref>PMID:12732628</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith C]]
[[Category: Bailey H]]
[[Category: Bountra C]]
[[Category: Burgess-Brown N]]
[[Category: Edwards A]]
[[Category: Fitzpatrick F]]
[[Category: Kopec J]]
[[Category: Oberholzer AE]]
[[Category: Strain-Damerell C]]
[[Category: Williams E]]
[[Category: Yue WW]]
[[Category: Von Delft F]]