View source for 5msz


==Lytic Polysaccharide Monooxygenase AA15 from Thermobia domestica in the Cu(I) State==
<StructureSection load='5msz' size='340' side='right'caption='[[5msz]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5msz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermobia_domestica Thermobia domestica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MSZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU1:COPPER+(I)+ION'>CU1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5msz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5msz OCA], [https://pdbe.org/5msz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5msz RCSB], [https://www.ebi.ac.uk/pdbsum/5msz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5msz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A2R2JFH0_THEDO A0A2R2JFH0_THEDO] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Thermobia domestica belongs to an ancient group of insects and has a remarkable ability to digest crystalline cellulose without microbial assistance. By investigating the digestive proteome of Thermobia, we have identified over 20 members of an uncharacterized family of lytic polysaccharide monooxygenases (LPMOs). We show that this LPMO family spans across several clades of the Tree of Life, is of ancient origin, and was recruited by early arthropods with possible roles in remodeling endogenous chitin scaffolds during development and metamorphosis. Based on our in-depth characterization of Thermobia's LPMOs, we propose that diversification of these enzymes toward cellulose digestion might have endowed ancestral insects with an effective biochemical apparatus for biomass degradation, allowing the early colonization of land during the Paleozoic Era. The vital role of LPMOs in modern agricultural pests and disease vectors offers new opportunities to help tackle global challenges in food security and the control of infectious diseases.

An ancient family of lytic polysaccharide monooxygenases with roles in arthropod development and biomass digestion.,Sabbadin F, Hemsworth GR, Ciano L, Henrissat B, Dupree P, Tryfona T, Marques RDS, Sweeney ST, Besser K, Elias L, Pesante G, Li Y, Dowle AA, Bates R, Gomez LD, Simister R, Davies GJ, Walton PH, Bruce NC, McQueen-Mason SJ Nat Commun. 2018 Feb 22;9(1):756. doi: 10.1038/s41467-018-03142-x. PMID:29472725<ref>PMID:29472725</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5msz" style="background-color:#fffaf0;"></div>

==See Also==
*[[Monooxygenase 3D structures|Monooxygenase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermobia domestica]]
[[Category: Bates R]]
[[Category: Besser K]]
[[Category: Bruce NC]]
[[Category: Ciano L]]
[[Category: Davies GJ]]
[[Category: Dowle A]]
[[Category: Dupree P]]
[[Category: Elias L]]
[[Category: Gomez L]]
[[Category: Hallam R]]
[[Category: Hemsworth GR]]
[[Category: Henrissat B]]
[[Category: Li Y]]
[[Category: McQueen-Mason S]]
[[Category: Pesante G]]
[[Category: Sabbadin F]]
[[Category: Tryfona T]]
[[Category: Walton PH]]