View source for 5mvb


==Solution structure of a human G-Quadruplex hybrid-2 form in complex with a Gold-ligand.==
<StructureSection load='5mvb' size='340' side='right'caption='[[5mvb]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5mvb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MVB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AUZ:bis(m2-Oxo)-bis(2-methyl-2,2-bipyridine)-di-gold(iii)'>AUZ</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mvb OCA], [https://pdbe.org/5mvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mvb RCSB], [https://www.ebi.ac.uk/pdbsum/5mvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mvb ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Telomeric G-quadruplexes have recently emerged as drug targets in cancer research. Herein, we present the first NMR structure of a telomeric DNA G-quadruplex that adopts the biologically relevant hybrid-2 conformation in a ligand-bound state. We solved the complex with a metalorganic gold(III) ligand that stabilizes G-quadruplexes. Analysis of the free and bound structures reveals structural changes in the capping region of the G-quadruplex. The ligand is sandwiched between one terminal G-tetrad and a flanking nucleotide. This complex structure involves a major structural rearrangement compared to the free G-quadruplex structure as observed for other G-quadruplexes in different conformations, invalidating simple docking approaches to ligand-G-quadruplex structure determination.

Solution NMR Structure of a Ligand/Hybrid-2-G-Quadruplex Complex Reveals Rearrangements that Affect Ligand Binding.,Wirmer-Bartoschek J, Bendel LE, Jonker HRA, Grun JT, Papi F, Bazzicalupi C, Messori L, Gratteri P, Schwalbe H Angew Chem Int Ed Engl. 2017 Jun 12;56(25):7102-7106. doi:, 10.1002/anie.201702135. Epub 2017 May 19. PMID:28524432<ref>PMID:28524432</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5mvb" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bazzicalupi C]]
[[Category: Bendel LE]]
[[Category: Gratteri P]]
[[Category: Gruen T]]
[[Category: Jonker HRA]]
[[Category: Messori L]]
[[Category: Schwalbe H]]
[[Category: Wirmer-Bartoschek J]]