View source for 5mxs


==Peptide-membrane interaction between targeting and lysis==
<StructureSection load='5mxs' size='340' side='right'caption='[[5mxs]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5mxs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MXS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mxs OCA], [https://pdbe.org/5mxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mxs RCSB], [https://www.ebi.ac.uk/pdbsum/5mxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mxs ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
Certain cationic peptides interact with biological membranes. These often-complex interactions can result in peptide targeting to the membrane, or in membrane permeation, rupture, and cell lysis. We investigated the relationship between the structural features of membrane-active peptides and these effects, to better understand these processes. To this end, we employed a computational method for morphing a membranolytic antimicrobial peptide into a nonmembranolytic mitochondrial targeting peptide by "directed simulated evolution." The results obtained demonstrate that superficially subtle sequence modifications can strongly affect the peptides' membranolytic and membrane-targeting abilities. Spectroscopic and computational analyses suggest that N- and C-terminal structural flexibility plays a crucial role in determining the mode of peptide-membrane interaction.

Peptide-Membrane Interaction between Targeting and Lysis.,Stutz K, Muller AT, Hiss JA, Schneider P, Blatter M, Pfeiffer B, Posselt G, Kanfer G, Kornmann B, Wrede P, Altmann KH, Wessler S, Schneider G ACS Chem Biol. 2017 Aug 8. doi: 10.1021/acschembio.7b00504. PMID:28763193<ref>PMID:28763193</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5mxs" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Blatter M]]