View source for 5n14


==NMR structure calculation of a composite Cys2His2 type zinc finger protein containing a non-peptide (or oligourea) helical domain==
<StructureSection load='5n14' size='340' side='right'caption='[[5n14]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5n14]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5N14 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OUD:(3~{S})-3-AZANYL-4-(CARBOXYAMINO)BUTANOIC+ACID'>OUD</scene>, <scene name='pdbligand=OUE:(4~{S})-4-AZANYL-5-(CARBOXYAMINO)PENTANOIC+ACID'>OUE</scene>, <scene name='pdbligand=OUH:[(2~{S})-2-AZANYL-3-(1~{H}-IMIDAZOL-5-YL)PROPYL]CARBAMIC+ACID'>OUH</scene>, <scene name='pdbligand=OUI:[(2~{S},3~{S})-2-AZANYL-3-METHYL-PENTYL]CARBAMIC+ACID'>OUI</scene>, <scene name='pdbligand=OUK:[(5~{S})-5-AZANYL-6-(CARBOXYAMINO)HEXYL]AZANIUM'>OUK</scene>, <scene name='pdbligand=OUR:[AZANYL-[[(4~{S})-4-AZANYL-5-(CARBOXYAMINO)PENTYL]AMINO]METHYLIDENE]AZANIUM'>OUR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5n14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n14 OCA], [https://pdbe.org/5n14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5n14 RCSB], [https://www.ebi.ac.uk/pdbsum/5n14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5n14 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/EGR1_HUMAN EGR1_HUMAN] Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Salgado G]]
[[Category: Venkateshaiah M VK]]