View source for 5odv


==Structure of Watermelon mosaic virus potyvirus.==
<SX load='5odv' size='340' side='right' viewer='molstar' caption='[[5odv]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5odv]] is a 48 chain structure with sequence from [https://en.wikipedia.org/wiki/Watermelon_mosaic_virus Watermelon mosaic virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ODV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ODV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5odv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5odv OCA], [https://pdbe.org/5odv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5odv RCSB], [https://www.ebi.ac.uk/pdbsum/5odv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5odv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q70J31_9POTV Q70J31_9POTV] 
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== Publication Abstract from PubMed ==
Potyviruses constitute the second largest genus of plant viruses and cause important economic losses in a large variety of crops; however, the atomic structure of their particles remains unknown. Infective potyvirus virions are long flexuous filaments where coat protein (CP) subunits assemble in helical mode bound to a monopartite positive-sense single-stranded RNA [(+)ssRNA] genome. We present the cryo-electron microscopy (cryoEM) structure of the potyvirus watermelon mosaic virus at a resolution of 4.0 A. The atomic model shows a conserved fold for the CPs of flexible filamentous plant viruses, including a universally conserved RNA binding pocket, which is a potential target for antiviral compounds. This conserved fold of the CP is widely distributed in eukaryotic viruses and is also shared by nucleoproteins of enveloped viruses with segmented (-)ssRNA (negative-sense ssRNA) genomes, including influenza viruses.

Potyvirus virion structure shows conserved protein fold and RNA binding site in ssRNA viruses.,Zamora M, Mendez-Lopez E, Agirrezabala X, Cuesta R, Lavin JL, Sanchez-Pina MA, Aranda MA, Valle M Sci Adv. 2017 Sep 20;3(9):eaao2182. doi: 10.1126/sciadv.aao2182. eCollection 2017, Sep. PMID:28948231<ref>PMID:28948231</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
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</SX>
[[Category: Large Structures]]
[[Category: Watermelon mosaic virus]]
[[Category: Agirrezabala X]]
[[Category: Aranda M]]
[[Category: Cuesta R]]
[[Category: Lavin JL]]
[[Category: Mendez-Lopez E]]
[[Category: Sanchez-Pina MA]]
[[Category: Valle M]]
[[Category: Zamora M]]