View source for 5qhp


==PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human FAM83B in complex with FMOPL000554a==
<StructureSection load='5qhp' size='340' side='right'caption='[[5qhp]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5qhp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QHP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QHP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.06&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GQM:5-methoxy-2-(1~{H}-pyrazol-3-yl)phenol'>GQM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qhp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qhp OCA], [https://pdbe.org/5qhp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qhp RCSB], [https://www.ebi.ac.uk/pdbsum/5qhp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qhp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FA83B_HUMAN FA83B_HUMAN] Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. May activate both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades.<ref>PMID:22886302</ref> <ref>PMID:23676467</ref> <ref>PMID:23912460</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Bufton JC]]
[[Category: Bullock AN]]
[[Category: Collins P]]
[[Category: Douangamath A]]
[[Category: Edwards A]]
[[Category: Fox AE]]
[[Category: Krojer T]]
[[Category: Pinkas DM]]
[[Category: Talon R]]
[[Category: Zhang R]]
[[Category: Von Delft F]]