View source for 5qsp


==PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z2856434929==
<StructureSection load='5qsp' size='340' side='right'caption='[[5qsp]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5qsp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QSP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QSP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.89&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LVV:4-[(4-methylphenyl)methyl]-1,4-thiazinane+1,1-dioxide'>LVV</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qsp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qsp OCA], [https://pdbe.org/5qsp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qsp RCSB], [https://www.ebi.ac.uk/pdbsum/5qsp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qsp ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/STAG1_HUMAN STAG1_HUMAN] STAG1-related intellectual disability-facial dysmorphism-gastroesophageal reflux syndrome. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/STAG1_HUMAN STAG1_HUMAN] Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Edwards A]]
[[Category: Gavard AE]]
[[Category: Gileadi O]]
[[Category: Katis VL]]
[[Category: Newman JA]]
[[Category: Von Delft F]]