View source for 5qtp


==PanDDA analysis group deposition -- Crystal Structure of NUDT5 in complex with AE-0227==
<StructureSection load='5qtp' size='340' side='right'caption='[[5qtp]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5qtp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QTP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QTP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.73&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PWJ:8-chloranyl-6-(trifluoromethyl)imidazo[1,2-a]pyridine-7-carbonitrile'>PWJ</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qtp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qtp OCA], [https://pdbe.org/5qtp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qtp RCSB], [https://www.ebi.ac.uk/pdbsum/5qtp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qtp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NUDT5_HUMAN NUDT5_HUMAN] Hydrolyzes with similar activities ADP-ribose ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity.<ref>PMID:17052728</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Burgess-Brown N]]
[[Category: Dubianok Y]]
[[Category: Edwards A]]
[[Category: Kovacs H]]
[[Category: Krojer T]]
[[Category: Moriaud F]]
[[Category: Strain-Damerell C]]
[[Category: Wright N]]
[[Category: Von Delft F]]