View source for 5szg


==Structure of the bMERB domain of Mical-3==
<StructureSection load='5szg' size='340' side='right'caption='[[5szg]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5szg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SZG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5SZG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5szg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5szg OCA], [https://pdbe.org/5szg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5szg RCSB], [https://www.ebi.ac.uk/pdbsum/5szg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5szg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MICA3_HUMAN MICA3_HUMAN] Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (By similarity). Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process.<ref>PMID:21596566</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Campos J]]
[[Category: Friese T]]
[[Category: Fu Y]]
[[Category: Gazdag EM]]
[[Category: Goody RS]]
[[Category: Itzen A]]
[[Category: Mueller MP]]
[[Category: Oprisko A]]
[[Category: Rai A]]