View source for 5tdl


==Crystal structure of prefusion-stabilized bovine RSV fusion glycoprotein (single-chain DS2-v1 variant: strain 391-2 sc9 DS-Cav1 Q98C Q361C)==
<StructureSection load='5tdl' size='340' side='right'caption='[[5tdl]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5tdl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovine_respiratory_syncytial_virus_(strain_Copenhagen) Bovine respiratory syncytial virus (strain Copenhagen)] and [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TDL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tdl OCA], [https://pdbe.org/5tdl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tdl RCSB], [https://www.ebi.ac.uk/pdbsum/5tdl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tdl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/WAC_BPT4 WAC_BPT4] Chaperone responsible for attachment of long tail fibers to virus particle. Forms the fibrous structure on the neck of the virion called whiskers. During phage assembly, 6 fibritin molecules attach to each virion neck through their N-terminal domains, to form a collar with six fibers ('whiskers').[https://www.uniprot.org/uniprot/FUS_BRSVC FUS_BRSVC] During virus entry, induces fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2. Interacts directly with heparan sulfate and may participate in virus attachment. Later in infection, proteins F expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis.[UniProtKB:P03420]
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</StructureSection>
[[Category: Escherichia virus T4]]
[[Category: Large Structures]]
[[Category: Chen L]]
[[Category: Kwong PD]]
[[Category: Zhang B]]