View source for 5tf2


==CRYSTAL STRUCTURE OF THE WD40 DOMAIN OF THE HUMAN PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN==
<StructureSection load='5tf2' size='340' side='right'caption='[[5tf2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5tf2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TF2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tf2 OCA], [https://pdbe.org/5tf2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tf2 RCSB], [https://www.ebi.ac.uk/pdbsum/5tf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tf2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PREB_HUMAN PREB_HUMAN] Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitement of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.[UniProtKB:Q9WTV0][UniProtKB:Q9WUQ2]  Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.[UniProtKB:Q9WTV0]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Chen Z]]
[[Category: Dong A]]
[[Category: Edwards AM]]
[[Category: He H]]
[[Category: Li Y]]
[[Category: Tempel W]]
[[Category: Tong Y]]
[[Category: Walker JR]]
[[Category: Wernimont A]]
[[Category: Zhang Q]]