View source for 5trs


==Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide PKS2144==
<StructureSection load='5trs' size='340' side='right'caption='[[5trs]], [[Resolution|resolution]] 3.08&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5trs]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TRS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TRS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.083567&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7HZ:N-TERT-BUTOXY-N~2~-(5-METHYL-1,2-OXAZOLE-3-CARBONYL)-L-ASPARAGINYL-O-METHYL-N-[(NAPHTHALEN-1-YL)METHYL]-L-SERINAMIDE'>7HZ</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5trs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5trs OCA], [https://pdbe.org/5trs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5trs RCSB], [https://www.ebi.ac.uk/pdbsum/5trs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5trs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PSA_MYCTU PSA_MYCTU] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The M.tuberculosis proteasome is able to cleave oligopeptides not only after hydrophobic but also after basic, acidic and small neutral residues. Among the identified substrates of the M.tuberculosis proteasome are the pupylated FabD, PanB and Mpa proteins. One function of the proteasome is to contribute to M.tuberculosis ability to resist killing by host macrophages, since the core proteasome is essential for persistence of the pathogen during the chronic phase of infection in mice. The mechanism of protection against bactericidal chemistries of the host's immune response probably involves the degradation of proteins that are irreversibly oxidized, nitrated, or nitrosated.<ref>PMID:16468985</ref> <ref>PMID:18059281</ref> 

==See Also==
*[[Proteasome 3D structures|Proteasome 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Fan H]]
[[Category: Hsu H-C]]
[[Category: Li H]]
[[Category: Lin G]]
[[Category: Nathan C]]
[[Category: Singh PK]]
[[Category: Sukenick G]]
[[Category: Wang R]]