View source for 5tuv


==Crystal structure of the E2F5-DP1-p107 ternary complex==
<StructureSection load='5tuv' size='340' side='right'caption='[[5tuv]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5tuv]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TUV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tuv OCA], [https://pdbe.org/5tuv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tuv RCSB], [https://www.ebi.ac.uk/pdbsum/5tuv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tuv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TFDP1_HUMAN TFDP1_HUMAN] Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).<ref>PMID:20176812</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Liban TJ]]
[[Category: Rubin SM]]
[[Category: Tripathi SM]]