View source for 5ufo


==Structure of RORgt bound to==
<StructureSection load='5ufo' size='340' side='right'caption='[[5ufo]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ufo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UFO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UFO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.802&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=87J:(S)-{4-CHLORO-2-METHOXY-3-[4-(METHYLSULFONYL)PHENYL]QUINOLIN-6-YL}(1-METHYL-1H-IMIDAZOL-5-YL)[6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]METHANOL'>87J</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ufo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ufo OCA], [https://pdbe.org/5ufo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ufo RCSB], [https://www.ebi.ac.uk/pdbsum/5ufo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ufo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Spurlino J]]