View source for 5ufr


==Structure of RORgt bound to==
<StructureSection load='5ufr' size='340' side='right'caption='[[5ufr]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ufr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UFR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UFR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.068&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=88J:(S)-[4-CHLORO-2-(DIMETHYLAMINO)-3-PHENYLQUINOLIN-6-YL](1-METHYL-1H-IMIDAZOL-5-YL)(PYRIDIN-4-YL)METHANOL'>88J</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ufr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ufr OCA], [https://pdbe.org/5ufr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ufr RCSB], [https://www.ebi.ac.uk/pdbsum/5ufr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ufr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Abad M]]
[[Category: Spurlino J]]