View source for 5uhi


==Structure of RORgt bound to==
<StructureSection load='5uhi' size='340' side='right'caption='[[5uhi]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5uhi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UHI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UHI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.198&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8A4:(R)-(4-CHLORO-2-METHOXY-3-{[4-(1H-PYRAZOL-1-YL)PHENYL]METHYL}QUINOLIN-6-YL)(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHANOL'>8A4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uhi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uhi OCA], [https://pdbe.org/5uhi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uhi RCSB], [https://www.ebi.ac.uk/pdbsum/5uhi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uhi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Abad M]]
[[Category: Spurlino J]]