View source for 5uuz


==Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Bacillus anthracis in the complex with IMP and the inhibitor P200==
<StructureSection load='5uuz' size='340' side='right'caption='[[5uuz]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5uuz]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UUZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.496&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8L4:3-(2-{[(4-CHLOROPHENYL)CARBAMOYL]AMINO}PROPAN-2-YL)-N-HYDROXYBENZENE-1-CARBOXIMIDAMIDE'>8L4</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uuz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uuz OCA], [https://pdbe.org/5uuz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uuz RCSB], [https://www.ebi.ac.uk/pdbsum/5uuz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uuz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A6L8P2U9_BACAN A0A6L8P2U9_BACAN] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964]

==See Also==
*[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]]
__TOC__
</StructureSection>
[[Category: Bacillus anthracis]]
[[Category: Large Structures]]
[[Category: Anderson WF]]
[[Category: Gollapalli D]]
[[Category: Gu M]]
[[Category: Hedstrom L]]
[[Category: Joachimiak A]]
[[Category: Kim Y]]
[[Category: Makowska-Grzyska M]]
[[Category: Maltseva N]]
[[Category: Mulligan R]]