View source for 5uyl


==70S ribosome bound with cognate ternary complex base-paired to A site codon (Structure II)==
<SX load='5uyl' size='340' side='right' viewer='molstar' caption='[[5uyl]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5uyl]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UYL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene>, <scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=PHE:PHENYLALANINE'>PHE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uyl OCA], [https://pdbe.org/5uyl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uyl RCSB], [https://www.ebi.ac.uk/pdbsum/5uyl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uyl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RL6_ECOLI RL6_ECOLI] This protein binds directly to at least 2 domains of the 23S ribosomal RNA, thus is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.[HAMAP-Rule:MF_01365]  Gentamicin-resistant mutations in this protein affect translation fidelity.[HAMAP-Rule:MF_01365]

==See Also==
*[[Elongation factor 3D structures|Elongation factor 3D structures]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
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</SX>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Demo G]]
[[Category: Grigorieff N]]
[[Category: Korostelev AA]]
[[Category: Loveland AB]]