View source for 5uze


==Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and P182==
<StructureSection load='5uze' size='340' side='right'caption='[[5uze]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5uze]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_perfringens_ATCC_13124 Clostridium perfringens ATCC 13124]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UZE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.27&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8L1:N-{4-CHLORO-3-[4-(TRIFLUOROMETHYL)-1,3-THIAZOL-2-YL]PHENYL}-N-(2-{3-[(1E)-N-HYDROXYETHANIMIDOYL]PHENYL}PROPAN-2-YL)UREA'>8L1</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uze OCA], [https://pdbe.org/5uze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uze RCSB], [https://www.ebi.ac.uk/pdbsum/5uze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uze ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A0H2YRZ7_CLOP1 A0A0H2YRZ7_CLOP1] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964]

==See Also==
*[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]]
__TOC__
</StructureSection>
[[Category: Clostridium perfringens ATCC 13124]]
[[Category: Large Structures]]
[[Category: Anderson WF]]
[[Category: Gollapalli DR]]
[[Category: Gu M]]
[[Category: Hedstrom L]]
[[Category: Joachimiak A]]
[[Category: Kim Y]]
[[Category: Makowska-Grzyska M]]
[[Category: Maltseva N]]
[[Category: Mulligan R]]