View source for 5v94


==Pekin duck egg lysozyme isoform III (DEL-III), cubic form==
<StructureSection load='5v94' size='340' side='right'caption='[[5v94]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5v94]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Anas_platyrhynchos Anas platyrhynchos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V94 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5V94 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5v94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v94 OCA], [https://pdbe.org/5v94 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5v94 RCSB], [https://www.ebi.ac.uk/pdbsum/5v94 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5v94 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LYSC1_ANAPL LYSC1_ANAPL] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Duck egg lysozyme (DEL) is a widely used model antigen owing to its capacity to bind with differential affinity to anti-chicken egg lysozyme antibodies. However, no structures of DEL have so far been reported, and the situation had been complicated by the presence of multiple isoforms and conflicting reports of primary sequence. Here, the structures of two DEL isoforms from the eggs of the commonly used Pekin duck (Anas platyrhynchos) are reported. Using structural analyses in combination with mass spectrometry, non-ambiguous DEL primary sequences are reported. Furthermore, the structures and sequences determined here enable rationalization of the binding affinity of DEL for well documented landmark anti-lysozyme antibodies.

Structural basis of antigen recognition: crystal structure of duck egg lysozyme.,Langley DB, Crossett B, Schofield P, Jackson J, Zeraati M, Maltby D, Christie M, Burnett D, Brink R, Goodnow C, Christ D Acta Crystallogr D Struct Biol. 2017 Nov 1;73(Pt 11):910-920. doi:, 10.1107/S2059798317013730. Epub 2017 Oct 25. PMID:29095163<ref>PMID:29095163</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5v94" style="background-color:#fffaf0;"></div>

==See Also==
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Anas platyrhynchos]]
[[Category: Large Structures]]
[[Category: Christ D]]
[[Category: Langley DB]]