View source for 5vc2


==Crystal structure of a serine hydroxymethyltransferase from Helicobacter pylori==
<StructureSection load='5vc2' size='340' side='right'caption='[[5vc2]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5vc2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_G27 Helicobacter pylori G27]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VC2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vc2 OCA], [https://pdbe.org/5vc2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vc2 RCSB], [https://www.ebi.ac.uk/pdbsum/5vc2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vc2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GLYA_HELPG GLYA_HELPG] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

==See Also==
*[[Serine hydroxymethyltransferase 3D structures|Serine hydroxymethyltransferase 3D structures]]
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</StructureSection>
[[Category: Helicobacter pylori G27]]
[[Category: Large Structures]]