View source for 5vqg


==Crystal structure of the extended Tudor domain from BmPAPI==
<StructureSection load='5vqg' size='340' side='right'caption='[[5vqg]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5vqg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombyx_mori Bombyx mori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VQG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vqg OCA], [https://pdbe.org/5vqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vqg RCSB], [https://www.ebi.ac.uk/pdbsum/5vqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vqg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TDRKH_BOMMO TDRKH_BOMMO] Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity (PubMed:23970546, PubMed:26919431). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins (Siwi or Ago3) and govern the methylation and subsequent repression of transposons (PubMed:23970546, PubMed:26919431). Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs: acts by recruiting the exonuclease PNLDC1/trimmer to Siwi-bound pre-piRNAs (PubMed:26919431).<ref>PMID:23970546</ref> <ref>PMID:26919431</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bombyx mori]]
[[Category: Large Structures]]
[[Category: Honda S]]
[[Category: Hubbard PA]]
[[Category: Kirino Y]]
[[Category: McNally R]]
[[Category: Murali R]]
[[Category: Ohtaki A]]
[[Category: Pan X]]