View source for 5vxj


==2.50 A resolution structure of IpaD from Shigella flexneri in complex with single-domain antibody JMK-E3==
<StructureSection load='5vxj' size='340' side='right'caption='[[5vxj]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5vxj]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri] and [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VXJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vxj OCA], [https://pdbe.org/5vxj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vxj RCSB], [https://www.ebi.ac.uk/pdbsum/5vxj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vxj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IPAD_SHIFL IPAD_SHIFL] Required for bacterial invasion of host cells. Controls IpaB and IpaC secretion, and the efficiency with which they are physically inserted into target cell membranes. These proteins are exported via TTSS to form a pore in the host membrane that allows the translocation of the other effectors into the host cytoplasm. Along with IpaB, is essential for both blocking secretion through the Mxi/Spa translocon in the absence of a secretion-inducing signal, and for controlling the level of secretion in the presence of this signal.<ref>PMID:7957095</ref> <ref>PMID:15731041</ref> 

==See Also==
*[[Antibody 3D structures|Antibody 3D structures]]
*[[3D structures of non-human antibody|3D structures of non-human antibody]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Shigella flexneri]]
[[Category: Vicugna pacos]]
[[Category: Barta ML]]
[[Category: Battaile KP]]
[[Category: Lovell S]]
[[Category: Picking WD]]
[[Category: Picking WL]]