View source for 5vxk


==2.55 A resolution structure of IpaD from Shigella flexneri in complex with single-domain antibody JMK-H2==
<StructureSection load='5vxk' size='340' side='right'caption='[[5vxk]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5vxk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri] and [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VXK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vxk OCA], [https://pdbe.org/5vxk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vxk RCSB], [https://www.ebi.ac.uk/pdbsum/5vxk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vxk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IPAD_SHIFL IPAD_SHIFL] Required for bacterial invasion of host cells. Controls IpaB and IpaC secretion, and the efficiency with which they are physically inserted into target cell membranes. These proteins are exported via TTSS to form a pore in the host membrane that allows the translocation of the other effectors into the host cytoplasm. Along with IpaB, is essential for both blocking secretion through the Mxi/Spa translocon in the absence of a secretion-inducing signal, and for controlling the level of secretion in the presence of this signal.<ref>PMID:7957095</ref> <ref>PMID:15731041</ref> 

==See Also==
*[[Antibody 3D structures|Antibody 3D structures]]
*[[3D structures of non-human antibody|3D structures of non-human antibody]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Shigella flexneri]]
[[Category: Vicugna pacos]]
[[Category: Barta ML]]
[[Category: Battaile KP]]
[[Category: Lovell S]]
[[Category: Picking WD]]
[[Category: Picking WL]]