View source for 5w54


==Cytokine-like Stress Response Peptide-2 in Manduca Sexta==
<StructureSection load='5w54' size='340' side='right'caption='[[5w54]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5w54]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Manduca_sexta Manduca sexta]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W54 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5W54 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5w54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w54 OCA], [https://pdbe.org/5w54 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5w54 RCSB], [https://www.ebi.ac.uk/pdbsum/5w54 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5w54 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A2D0TCH0_MANSE A0A2D0TCH0_MANSE] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Manduca sexta stress response peptide-2 (SRP2) is predicted to be a 25-residue peptide (FGVKDGKCPSGRVRRLGICVPDDDY), which may function as an insect cytokine to regulate immune responses. Produced as an inactive precursor, endogenous proSRP2 is probably converted to active SRP2 by limited proteolysis in response to invading pathogens, along with prophenoloxidase and pro-Spatzle activation. In addition to immunity, SRP2 may control head morphogenesis or other developmental processes in the lepidopteran insect. We have examined the profiles of SRP2 gene expression in terms of immune induction capacity, tissue specificity, and developmental changes. To gain insights into its functions, we chemically synthesized SRP2, injected the peptide solution into naive larvae, and detected significant up-regulation of several antimicrobial peptide genes. We determined the 3D molecular structure in solution of SRP2 by two-dimensional 1H-1H NMR spectroscopy. SRP2 has an ordered structure, which is composed of two short beta-strands at regions R12 - R15 and I18 - V20, one type-I' beta-turn at region R15 - I18, and a half turn at region C8 - S10 in its welldefined core stabilized by a covalent disulfide bond between C8 and C19. The secondary and tertiary structures are further stabilized by hydrogen bonds. Possible relationships between the structure and function are also discussed.

Solution Structure and Expression Profile of an Insect Cytokine: Manduca sexta Stress Response Peptide-2.,Schrag LG, Cao X, Herrera AI, Wang Y, Jiang H, Prakash O Protein Pept Lett. 2017;24(1):3-11. doi: 10.2174/0929866524666161121142840. PMID:27903232<ref>PMID:27903232</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5w54" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Manduca sexta]]
[[Category: Herrera AI]]
[[Category: Prakash O]]
[[Category: Schrag LG]]