View source for 5wua


==Structure of a Pancreatic ATP-sensitive Potassium Channel==
<SX load='5wua' size='340' side='right' viewer='molstar' caption='[[5wua]], [[Resolution|resolution]] 5.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5wua]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Golden_hamster Golden hamster] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WUA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5WUA FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Kcnj11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5wua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wua OCA], [http://pdbe.org/5wua PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wua RCSB], [http://www.ebi.ac.uk/pdbsum/5wua PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wua ProSAT]</span></td></tr>
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== Function ==
[[http://www.uniprot.org/uniprot/KCJ11_MOUSE KCJ11_MOUSE]] This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (By similarity). 
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== Publication Abstract from PubMed ==
ATP-sensitive potassium channels (KATP) couple intracellular ATP levels with membrane excitability. These channels play crucial roles in many essential physiological processes and have been implicated extensively in a spectrum of metabolic diseases and disorders. To gain insight into the mechanism of KATP, we elucidated the structure of a hetero-octameric pancreatic KATP channel in complex with a non-competitive inhibitor glibenclamide by single-particle cryoelectron microscopy to 5.6-A resolution. The structure shows that four SUR1 regulatory subunits locate peripherally and dock onto the central Kir6.2 channel tetramer through the SUR1 TMD0-L0 fragment. Glibenclamide-bound SUR1 uses TMD0-L0 fragment to stabilize Kir6.2 channel in a closed conformation. In another structural population, a putative co-purified phosphatidylinositol 4,5-bisphosphate (PIP2) molecule uncouples Kir6.2 from glibenclamide-bound SUR1. These structural observations suggest a molecular mechanism for KATP regulation by anti-diabetic sulfonylurea drugs, intracellular adenosine nucleotide concentrations, and PIP2 lipid.

Structure of a Pancreatic ATP-Sensitive Potassium Channel.,Li N, Wu JX, Ding D, Cheng J, Gao N, Chen L Cell. 2017 Jan 12;168(1-2):101-110.e10. doi: 10.1016/j.cell.2016.12.028. Epub, 2017 Jan 12. PMID:28086082<ref>PMID:28086082</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 5wua" style="background-color:#fffaf0;"></div>

==See Also==
*[[Potassium channel 3D structures|Potassium channel 3D structures]]
== References ==
<references/>
__TOC__
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[[Category: Golden hamster]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Chen, L]]
[[Category: Gao, N]]
[[Category: Li, N]]
[[Category: Wu, J X]]
[[Category: Abc transporter]]
[[Category: Channel]]
[[Category: Katp]]
[[Category: Kir]]
[[Category: Transport protein]]