View source for 5xdz


==Crystal structure of zebrafish SNX25 PX domain==
<StructureSection load='5xdz' size='340' side='right'caption='[[5xdz]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5xdz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XDZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XDZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xdz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xdz OCA], [https://pdbe.org/5xdz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xdz RCSB], [https://www.ebi.ac.uk/pdbsum/5xdz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xdz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/C6K2H9_DANRE C6K2H9_DANRE] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
SNX25, a regulator of GPCR signaling-phox-homology (PX) domain containing sorting nexin (SNX) member, has been proposed to be involved in the lysosomal degradation of the transforming growth factor beta receptor and the development of temporal lobe epilepsy. Targeting to the endosomal membranes by the specific binding of phosphorylated phosphatidylinositols (PIPs) through the PX domain is critical for the function of SNXs. However, the mechanism for SNX25-PX targeting to the endosomes remains unclear. Here, we demonstrate that the PX domain of zebrafish SNX25 (zSNX25-PX) is capable of binding to PI3P only in its dimeric form. We also present the crystal structure of zSNX25-PX. Combined with biochemical experiments, we further identify a potential PI3P-binding region and propose a novel PI-binding model based on dimerization in the PX domain of SNXs.

Structure of the PX domain of SNX25 reveals a novel phospholipid recognition model by dimerization in the PX domain.,Su K, Xu T, Yu Z, Zhu J, Zhang Y, Wu M, Xiong Y, Liu J, Xu J FEBS Lett. 2017 Jul;591(13):2011-2018. doi: 10.1002/1873-3468.12688. Epub 2017, Jun 11. PMID:28542875<ref>PMID:28542875</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5xdz" style="background-color:#fffaf0;"></div>

==See Also==
*[[Sorting nexin 3D structures|Sorting nexin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Danio rerio]]
[[Category: Large Structures]]
[[Category: Liu J]]
[[Category: Su K]]
[[Category: Xu J]]
[[Category: Zhang Y]]