View source for 5xkn


==Crystal structure of plant receptor ERL2 in complexe with EPFL4==
<StructureSection load='5xkn' size='340' side='right'caption='[[5xkn]], [[Resolution|resolution]] 3.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5xkn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XKN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.651&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xkn OCA], [https://pdbe.org/5xkn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xkn RCSB], [https://www.ebi.ac.uk/pdbsum/5xkn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xkn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/EPFL4_ARATH EPFL4_ARATH] Acts primarily as positive regulator of inflorescence growth. Endodermal expression is sufficient for proper inflorescence architecture (PubMed:22474391). Redundantly involved with EPFL6 in procambial development regulation. Controls stomatal patterning. Mediates stomatal development inhibition. TMM (AC Q9SSD1) functions to dampen or block CLL2 signaling. Acts as a growth-regulatory ligand for ERECTA family receptors.<ref>PMID:19435754</ref> <ref>PMID:21862708</ref> <ref>PMID:22474391</ref> <ref>PMID:23881395</ref> 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Stomata are microscopic openings that allow for the exchange of gases between plants and the environment. In Arabidopsis, stomatal patterning is specified by the ERECTA family (ERf) receptor kinases (RKs), the receptor-like protein (RLP) TOO MANY MOUTHS (TMM), and EPIDERMAL PATTERNING FACTOR (EPF) peptides. Here we show that TMM and ER or ER-LIKE1 (ERL1) form constitutive complexes, which recognize EPF1 and EPF2, but the single ERfs do not. TMM interaction with ERL1 creates a binding pocket for recognition of EPF1 and EPF2, indicating that the constitutive TMM-ERf complexes function as the receptors of EPF1 and EPF2. EPFL9 competes with EPF1 and EPF2 for binding to the ERf-TMM complex. EPFL4 and EPFL6, however, are recognized by the single ERfs without the requirement of TMM. In contrast to EPF1,2, the interaction of EPFL4,6 with an ERf is greatly reduced in the presence of TMM. Taken together, our data demonstrate that TMM dictates the specificity of ERfs for the perception of different EPFs, thus functioning as a specificity switch for the regulation of the activities of ERfs.

A receptor-like protein acts as a specificity switch for the regulation of stomatal development.,Lin G, Zhang L, Han Z, Yang X, Liu W, Li E, Chang J, Qi Y, Shpak ED, Chai J Genes Dev. 2017 May 1;31(9):927-938. doi: 10.1101/gad.297580.117. Epub 2017 May, 23. PMID:28536146<ref>PMID:28536146</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5xkn" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Chai J]]
[[Category: Lin G]]