View source for 5xoh


==Crystal structure of bergaptol o-methyltransferase complex==
<StructureSection load='5xoh' size='340' side='right'caption='[[5xoh]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5xoh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Peucedanum_praeruptorum Peucedanum praeruptorum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XOH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XOH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8B6:4-oxidanylfuro[3,2-g]chromen-7-one'>8B6</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xoh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xoh OCA], [https://pdbe.org/5xoh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xoh RCSB], [https://www.ebi.ac.uk/pdbsum/5xoh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xoh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BMT_KITPR BMT_KITPR] O-methyltransferase involved in the biosynthesis of furocoumarins natural products such as bergapten, a photosensitizer used for medical purpose such as treating psoriasis and vitiligo or facilitating resistance to microbial infection and other stresses (PubMed:30934718, PubMed:27252733, PubMed:31666994). Catalyzes specifically the methylation of bergaptol (PubMed:30934718, PubMed:27252733, PubMed:31666994). Not active on xanthotol, isoscopoletin, scopoletin and esculetin (PubMed:30934718, PubMed:27252733).<ref>PMID:27252733</ref> <ref>PMID:30934718</ref> <ref>PMID:31666994</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Peucedanum praeruptorum]]
[[Category: Zeng Z]]
[[Category: Zhou Y]]