View source for 5xqm


==NMR solution structure of SMO1, Sumo homologue in Caenorhabditis elegans==
<StructureSection load='5xqm' size='340' side='right'caption='[[5xqm]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5xqm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XQM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XQM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xqm OCA], [https://pdbe.org/5xqm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xqm RCSB], [https://www.ebi.ac.uk/pdbsum/5xqm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xqm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SUMO_CAEEL SUMO_CAEEL] Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process (PubMed:11806825). Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction (PubMed:11806825, PubMed:25475837). Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17 (PubMed:15107848, PubMed:16701625). Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates (PubMed:15466489, PubMed:15689373, PubMed:15990876, PubMed:24349540). Probably by sumoylating bet-1, prevents muscle myosin depletion in aging adults probably by preventing myoblast growth factor receptor egl-15 overexpression (PubMed:24285704). Plays a role in the attenuation of the let-60/ras pathway (PubMed:24349540, PubMed:24285704).<ref>PMID:11806825</ref> <ref>PMID:15107848</ref> <ref>PMID:15466489</ref> <ref>PMID:15689373</ref> <ref>PMID:15990876</ref> <ref>PMID:16701625</ref> <ref>PMID:24285704</ref> <ref>PMID:24349540</ref> 

==See Also==
*[[SUMO 3D Structures|SUMO 3D Structures]]
== References ==
<references/>
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</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Large Structures]]
[[Category: Das R]]
[[Category: Gowda CM]]
[[Category: Surana P]]