View source for 5xyl


==Solution Structure of Skp1 from Homo sapiens==
<StructureSection load='5xyl' size='340' side='right'caption='[[5xyl]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5xyl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XYL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xyl OCA], [https://pdbe.org/5xyl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xyl RCSB], [https://www.ebi.ac.uk/pdbsum/5xyl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xyl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SKP1_HUMAN SKP1_HUMAN] Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110.<ref>PMID:16209941</ref> <ref>PMID:20181953</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bhattacharya A]]
[[Category: Dantu SC]]
[[Category: Kachariya NN]]
[[Category: Kumar A]]
[[Category: Shukla VK]]