View source for 5xz4


==The X-tay structure of Bumblebee PGRP-SA==
<StructureSection load='5xz4' size='340' side='right'caption='[[5xz4]], [[Resolution|resolution]] 1.41&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5xz4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombus Bombus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XZ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XZ4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.41&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xz4 OCA], [https://pdbe.org/5xz4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xz4 RCSB], [https://www.ebi.ac.uk/pdbsum/5xz4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xz4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A452CSL6_9HYME A0A452CSL6_9HYME] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The peptidoglycan recognition protein SAs (PGRP-SAs) from Bombus ignitus (Bi-PGRP-SA), Apis mellifera (Am-PGRP-SA), and Megachile rotundata PGRP-SA (Mr-PGRP-SA) exhibit an intrinsic ability to preferentially bind to Dap-type peptidoglycan (PGN) from Bacillus subtilis rather than Lys-type PGN from Micrococcus luteus This ability is more analogous to the binding exhibited by PGRP-LCx and PGRP-SD than to that exhibited by PGRP-SA in Drosophila Moreover, Bi-PGRP-SA and Am-PGRP-SA share greater sequence identity with Drosophila PGRP-LCx than with PGRP-SD and retain several conserved contact residues, including His(37)/His(38), His(60)/His(61), Trp(66)/Trp(67), Ala(150)/Ala(151), and Thr(151)/Thr(152) However, the corresponding contact residue Arg(85) is not a major anchor residue in bees (e.g., bumblebees, honeybees, and leaf-cutting bees), and an in silico analysis indicated that the residues Thr(151)/Thr(152) and Ser(153)/Ser(154) of Bi-PGRP-SA and Am-PGRP-SA are deduced to be anchor residues. In addition, the nonconserved residues Asp(67) in Bi-PGRP-SA and Mr-PGRP-SA and His(68) in Am-PGRP-SA are deduced to be involved in the binding to Dap-type PGNs in bumblebees, honeybees, and leaf-cutting bees. We conclude that the structures and specificities of PGRP-SAs in bees are more analogous to those of PGRP-LCx than to those of Drosophila PGRP-SA. This phenomenon might be explained by the fact that the evolutionary clade of Hymenoptera is more ancient than that of Diptera.

Structural Insights into the Preferential Binding of PGRP-SAs from Bumblebees and Honeybees to Dap-Type Peptidoglycans Rather than Lys-Type Peptidoglycans.,Liu Y, Zhao X, Huang J, Chen M, An J J Immunol. 2019 Jan 1;202(1):249-259. doi: 10.4049/jimmunol.1800439. Epub 2018, Dec 3. PMID:30510067<ref>PMID:30510067</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5xz4" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bombus]]
[[Category: Large Structures]]
[[Category: An JD]]
[[Category: Huang JX]]
[[Category: Liu YJ]]
[[Category: Zhao XM]]