View source for 5yej


==Crystal structure of BioQ with its naturel double-stranded DNA operator==
<StructureSection load='5yej' size='340' side='right'caption='[[5yej]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5yej]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YEJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YEJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.698&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yej OCA], [https://pdbe.org/5yej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yej RCSB], [https://www.ebi.ac.uk/pdbsum/5yej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yej ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0QX69_MYCS2 A0QX69_MYCS2] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.[ARBA:ARBA00002856]

==See Also==
*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Mycolicibacterium smegmatis MC2 155]]
[[Category: Synthetic construct]]
[[Category: Guan ZY]]
[[Category: Yan L]]
[[Category: Zou TT]]