View source for 5yfg


==SOLUTION STRUCTURE OF HUMAN MOG1==
<StructureSection load='5yfg' size='340' side='right'caption='[[5yfg]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5yfg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YFG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YFG FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yfg OCA], [https://pdbe.org/5yfg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yfg RCSB], [https://www.ebi.ac.uk/pdbsum/5yfg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yfg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MOG1_HUMAN MOG1_HUMAN] May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A.<ref>PMID:11290418</ref> <ref>PMID:18184654</ref> 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Stable transmission of genetic information during cell division requires faithful mitotic spindle assembly and chromosome segregation. The Ran GTPase plays a key role in mitotic spindle assembly. However, how the generation of a chemical gradient of Ran-GTP at the spindle is coupled to mitotic post-translational modifications has never been characterized. Here, we solved the complex structure of Ran with the nucleotide release factor Mog1 and delineated a novel mitosis-specific acetylation-regulated Ran-Mog1 interaction during chromosome segregation. Our structure-guided functional analyses revealed that Mog1 competes with RCC1 for Ran binding in a GTP/GDP-dependent manner. Biochemical characterization demonstrated that Mog1-bound Ran prevents RCC1 binding and subsequent GTP loading. Surprisingly, Ran is a bona fide substrate of TIP60, and the acetylation of Lys134 by TIP60 liberates Mog1 from Ran binding during mitosis. Importantly, this acetylation-elicited switch of Ran binding to RCC1 promotes high level of Ran-GTP, which is essential for chromosome alignment. These results establish a previously uncharacterized regulatory mechanism in which TIP60 provides a homeostatic control of Ran-GTP level by tuning Ran effector binding for chromosome segregation in mitosis.

Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation.,Bao X, Liu H, Liu X, Ruan K, Zhang Y, Zhang Z, Hu Q, Liu Y, Akram S, Zhang J, Gong Q, Wang W, Yuan X, Li J, Zhao L, Dou Z, Tian R, Yao X, Wu J, Shi Y J Mol Cell Biol. 2017 Oct 6. doi: 10.1093/jmcb/mjx045. PMID:29040603<ref>PMID:29040603</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5yfg" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bao X]]
[[Category: Hu Q]]
[[Category: Liu H]]
[[Category: Liu Y]]