View source for 5yhu


==Crystal structure of the DNA-binding domain of human myelin-gene regulatory factor==
<StructureSection load='5yhu' size='340' side='right'caption='[[5yhu]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5yhu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YHU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YHU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yhu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yhu OCA], [https://pdbe.org/5yhu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yhu RCSB], [https://www.ebi.ac.uk/pdbsum/5yhu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yhu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MYRF_HUMAN MYRF_HUMAN] Myelin regulatory factor: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes (PubMed:23966832).<ref>PMID:23966832</ref>   Myelin regulatory factor, C-terminal: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage.<ref>PMID:23966832</ref>   Myelin regulatory factor, N-terminal: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (PubMed:23966832).<ref>PMID:23966832</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chen B]]
[[Category: Ye S]]
[[Category: Zhang R]]
[[Category: Zhu Y]]