View source for 5ykj


==Structural basis of the thiol resolving mechanism in yeast mitochondrial 1-Cys peroxiredoxin via glutathione/thioredoxin systems==
<StructureSection load='5ykj' size='340' side='right'caption='[[5ykj]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ykj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YKJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ykj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ykj OCA], [https://pdbe.org/5ykj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ykj RCSB], [https://www.ebi.ac.uk/pdbsum/5ykj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ykj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PRX1_YEAST PRX1_YEAST] Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Involved in mitochondrial protection of cadmium-induced oxidative stress.<ref>PMID:10821871</ref> <ref>PMID:19332553</ref> <ref>PMID:20059400</ref> 

==See Also==
*[[Peroxiredoxin 3D structures|Peroxiredoxin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Bao R]]
[[Category: He LH]]
[[Category: Li CC]]
[[Category: Li T]]
[[Category: Liu L]]
[[Category: Peng CT]]
[[Category: Song YJ]]
[[Category: Yang J]]
[[Category: Yang MJ]]
[[Category: Zhao C]]
[[Category: Zhao NL]]
[[Category: Zhu YB]]