View source for 5ysx


==Structure of P domain of GII.2 Noroviruses==
<StructureSection load='5ysx' size='340' side='right'caption='[[5ysx]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ysx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus_GII Norovirus GII]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YSX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YSX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.202&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ysx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ysx OCA], [https://pdbe.org/5ysx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ysx RCSB], [https://www.ebi.ac.uk/pdbsum/5ysx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ysx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A2R3BZ02_9CALI A0A2R3BZ02_9CALI] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Background: During 2016-2017, the previously rare GII.P16-GII.2 norovirus suddenly emerged as the predominant genotype causing gastroenteritis outbreaks in China and other countries. Its origin, phylodynamics, and mechanism behind the predominance remain unclear. Methods: Bayesian phylogenetic analyses were performed on 180 full capsid and 150 polymerase sequences of 2016-2017 GII.P16-GII.2 noroviruses in China, and those for all publicly available GII.P16 and GII.2 sequences. Saliva-based histo-blood group antigen (HBGA) binding assays and crystal structural analysis were conducted by using the P proteins of 2016-2017 GII.P16-GII.2 noroviruses. Results: The reemerging GII.P16-GII.2 norovirus showed a rapid genetic diversification after its emergence in 2012-2013. The antigenicity and HBGA binding profile of the early 2016-2017 and pre-2016 GII.2 noroviruses were similar. A further variant with a single Val256Ile mutation and the conventionally orientated Asp382 in the VP1 protein showed an expanded HBGA-binding spectrum. Mutations on the surface of polymerase that could alter its function were seen, which may help to accelerate the VP1 gene evolution to 5.5 x 10-3 substitutions per site per year. This virus can be traced back to Pearl River Delta, China. Conclusions: Our findings provide new insights into GII.2 norovirus epidemics and highlight the necessity of enhanced global surveillance for potential epidemics of rare-genotype noroviruses.

Genetic Analysis of Reemerging GII.P16-GII.2 Noroviruses in 2016-2017 in China.,Ao Y, Cong X, Jin M, Sun X, Wei X, Wang J, Zhang Q, Song J, Yu J, Cui J, Qi J, Tan M, Duan Z J Infect Dis. 2018 Jun 5;218(1):133-143. doi: 10.1093/infdis/jiy182. PMID:29617875<ref>PMID:29617875</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5ysx" style="background-color:#fffaf0;"></div>

==See Also==
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Norovirus GII]]
[[Category: Ao Y]]
[[Category: Duan Z]]