View source for 5yxk


==High resolution crystal structure of Human B7-2 IgV domain in P21 space group==
<StructureSection load='5yxk' size='340' side='right'caption='[[5yxk]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5yxk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YXK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yxk OCA], [https://pdbe.org/5yxk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yxk RCSB], [https://www.ebi.ac.uk/pdbsum/5yxk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yxk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CD86_HUMAN CD86_HUMAN] Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Lankipalli S]]
[[Category: Ramagopal UA]]