View source for 5yz5


==Crystal Structure of Human CRMP-2 with T509D-T514D-S518D-S522D mutations==
<StructureSection load='5yz5' size='340' side='right'caption='[[5yz5]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5yz5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YZ5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yz5 OCA], [https://pdbe.org/5yz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yz5 RCSB], [https://www.ebi.ac.uk/pdbsum/5yz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yz5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DPYL2_HUMAN DPYL2_HUMAN] Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis.<ref>PMID:11477421</ref> <ref>PMID:15466863</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Aoki M]]
[[Category: Imasaki T]]
[[Category: Nitta E]]
[[Category: Nitta R]]
[[Category: Sakai N]]
[[Category: Shirouzu M]]
[[Category: Sumi T]]