View source for 5yzz


==AtVAL1 B3 domain in complex with 13bp-DNA==
<StructureSection load='5yzz' size='340' side='right'caption='[[5yzz]], [[Resolution|resolution]] 2.58&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5yzz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YZZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YZZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.58&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yzz OCA], [https://pdbe.org/5yzz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yzz RCSB], [https://www.ebi.ac.uk/pdbsum/5yzz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yzz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VAL1_ARATH VAL1_ARATH] Transcriptional repressor of gene expression involved in embryonic pathways, such as LEC1, ABI3, and FUS3. Repressor of the sugar-inducible genes involved in the seed maturation program in seedlings. Plays an essential role in regulating the transition from seed maturation to seedling growth. Functionally redundant with VAL2/HSL1.<ref>PMID:15894743</ref> <ref>PMID:17158584</ref> <ref>PMID:17267611</ref> 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Vernalization is a pivotal stage for some plants involving many epigenetic changes during cold exposure. In Arabidopsis, an essential step in vernalization for further flowering is successful silence the potent floral repressor Flowering Locus C (FLC) by repressing histone mark. AtVal1 is a multi-function protein containing five domains that participate into many recognition processes and is validated to recruit the repress histone modifier PHD-PRC2 complex and interact with components of the ASAP complex target to the FLC nucleation region through recognizing a cis element known as CME (cold memory element) by its plant-specific B3 domain. Here, we determine the crystal structure of the B3 domain in complex with Sph/RY motif in CME. Our structural analysis reveals the specific DNA recognition by B3 domain, combined with our in vitro experiments, we provide the structural insight into the important implication of AtVAL1-B3 domain in flowering process.

Structural insight into the role of VAL1 B3 domain for targeting to FLC locus in Arabidopsis thaliana.,Wu B, Zhang M, Su S, Liu H, Gan J, Ma J Biochem Biophys Res Commun. 2018 Jun 22;501(2):415-422. doi:, 10.1016/j.bbrc.2018.05.002. Epub 2018 May 10. PMID:29733847<ref>PMID:29733847</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5yzz" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Wu BX]]
[[Category: Zhang MM]]