View source for 5z2g


==Crystal Structure of L-amino acid oxidase from venom of Naja atra==
<StructureSection load='5z2g' size='340' side='right'caption='[[5z2g]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5z2g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z2G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Z2G FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.676&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5z2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z2g OCA], [https://pdbe.org/5z2g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5z2g RCSB], [https://www.ebi.ac.uk/pdbsum/5z2g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5z2g ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/OXLA_NAJAT OXLA_NAJAT] Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme (PubMed:18180850). Shows activity on L-Leu (PubMed:18180850). Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, apoptosis of vascular endothelial cells or tumor cell lines, antibacterial and antiparasitic activities (By similarity). This protein induces platelet aggregation by both hydrogen peroxide production and binding to platelet membrane proteins (that would enhance the sensitivity of platelets to hydrogen peroxide). Effects of snake L-amino oxidases on platelets are controversial, since they either induce aggregation or inhibit agonist-induced aggregation. These different effects are probably due to different experimental conditions.[UniProtKB:P0CC17]<ref>PMID:18180850</ref> 

==See Also==
*[[Amino acid oxidase 3D structures|Amino acid oxidase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Naja atra]]
[[Category: Chiang LC]]
[[Category: Chien KY]]
[[Category: Kumar JV]]
[[Category: Lin CC]]
[[Category: Lin TH]]
[[Category: Wu WG]]