View source for 5zcy


==Crystal structure of archaeal translation initiation factor 1 at 1.5 Angstroms resolution==
<StructureSection load='5zcy' size='340' side='right'caption='[[5zcy]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5zcy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZCY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZCY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NO2:NITRITE+ION'>NO2</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zcy OCA], [https://pdbe.org/5zcy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zcy RCSB], [https://www.ebi.ac.uk/pdbsum/5zcy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zcy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SUI1_PYRHO SUI1_PYRHO] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The archaeal translation initiation factor 1 (aIF1) is reported to be functionally homologous to the eukaryotic translation initiation factor 1 (eIF1). However, lack of a structural comparison between aIF1 and eIF1 has limited our understanding of the structural (dis)similarities. Herein, we have determined the three-dimensional crystal structure of an open reading frame PH1771.1 encoding aIF1 in Pyrococcus horikoshii OT3. Results reveal that although aIF1 has low sequence similarity with eIF1, high structural homology exists between the two proteins. Nonetheless, notable critical differences between aIF1 and eIF1 could still be perceived at the beta1 -beta2 basic loop, the acidic loop and the solvent-exposed surface. These differences might lead to a slightly divergent mode of action of aIF1 during archaeal translation initiation.

Archaeal and eukaryal translation initiation factor 1 differ in their RNA interacting loops.,Gogoi P, Kanaujia SP FEBS Lett. 2018 Apr 2. doi: 10.1002/1873-3468.13044. PMID:29608219<ref>PMID:29608219</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5zcy" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pyrococcus horikoshii OT3]]
[[Category: Gogoi P]]
[[Category: Kanaujia SP]]