View source for 5zgg


==NMR structure of p75NTR transmembrane domain in complex with NSC49652==
<StructureSection load='5zgg' size='340' side='right'caption='[[5zgg]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5zgg]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZGG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZGG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9F6:(2E)-1-(2-hydroxyphenyl)-3-(pyridin-3-yl)prop-2-en-1-one'>9F6</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zgg OCA], [http://pdbe.org/5zgg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zgg RCSB], [http://www.ebi.ac.uk/pdbsum/5zgg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zgg ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/TNR16_HUMAN TNR16_HUMAN]] Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.<ref>PMID:14966521</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Ibanez, C]]
[[Category: Lin, Z]]
[[Category: Complex]]
[[Category: Membrane protein]]
[[Category: Transmembrane]]