View source for 5zkv


==Solution structure of molten globule state of L94G mutant of horse cytochrome-c==
<StructureSection load='5zkv' size='340' side='right'caption='[[5zkv]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5zkv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZKV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR,  models</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEC:HEME+C'>HEC</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zkv OCA], [https://pdbe.org/5zkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zkv RCSB], [https://www.ebi.ac.uk/pdbsum/5zkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zkv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CYC_HORSE CYC_HORSE] Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.  Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity).

==See Also==
*[[Cytochrome C 3D structures|Cytochrome C 3D structures]]
__TOC__
</StructureSection>
[[Category: Equus caballus]]
[[Category: Large Structures]]
[[Category: Ahmad F]]
[[Category: Hassan MI]]
[[Category: Islam A]]
[[Category: Naiyer A]]
[[Category: Sundd M]]