View source for 5zrn


==Inhibitor bound crystal structure of N-terminal domain of FACL13 from Mycobacterium tuberculosis==
<StructureSection load='5zrn' size='340' side='right'caption='[[5zrn]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5zrn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_CDC1551 Mycobacterium tuberculosis CDC1551]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZRN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZRN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.37&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JSA:5-O-{[(1R)-1-hydroxydodecyl]sulfamoyl}adenosine'>JSA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zrn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zrn OCA], [https://pdbe.org/5zrn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zrn RCSB], [https://www.ebi.ac.uk/pdbsum/5zrn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zrn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FAC13_MYCTU FAC13_MYCTU] Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension. It has preference for the fatty acid with long chain length in the following order: hexacosanoic acid (C26), tetracosanoic acid (C24) and palmitic acid (C16).<ref>PMID:15937179</ref> <ref>PMID:20027301</ref> <ref>PMID:22560731</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis CDC1551]]
[[Category: Goyal A]]
[[Category: Sankaranarayanan R]]