View source for 5zur


==Achromobacter Dh1f Bacterioferritin==
<StructureSection load='5zur' size='340' side='right'caption='[[5zur]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5zur]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Achromobacter_sp._DH1f Achromobacter sp. DH1f]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZUR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZUR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zur OCA], [https://pdbe.org/5zur PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zur RCSB], [https://www.ebi.ac.uk/pdbsum/5zur PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zur ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A3F2YLV4_9BURK A0A3F2YLV4_9BURK] Iron-storage protein.[RuleBase:RU000623]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Bacterioferritins (Bfrs) are ferritin-like molecules with a hollow spherical 24-mer complex design that are unique to bacterial and archaeal species. They play a critical role in storing iron(III) within the complex at concentrations much higher than the feasible solubility limits of iron(III), thus maintaining iron homeostasis within cells. Here, the crystal structure of bacterioferritin from Achromobacter (Ach Bfr) that crystallized serendipitously during a crystallization attempt of an unrelated mycobacterial protein is reported at 1.95 A resolution. Notably, Fe atoms were bound to the structure along with a porphyrin ring sandwiched between the subunits of a dimer. Furthermore, the dinuclear ferroxidase center of Ach Bfr has only a single iron bound, in contrast to the two Fe atoms in other Bfrs. The structure of Ach Bfr clearly demonstrates the substitution of a glutamate residue, which is involved in the interaction with the second Fe atom, by a threonine and the consequent absence of another Fe atom there. The iron at the dinuclear center has a tetravalent coordination, while a second iron with a hexavalent coordination was found within the porphyrin ring, generating a heme moiety. Achromobacter spp. are known opportunistic pathogens; this structure enhances the current understanding of their iron metabolism and regulation, and importantly will be useful in the design of small-molecule inhibitors against this protein through a structure-guided approach.

Serendipitous crystallization and structure determination of bacterioferritin from Achromobacter.,Dwivedy A, Jha B, Singh KH, Ahmad M, Ashraf A, Kumar D, Biswal BK Acta Crystallogr F Struct Biol Commun. 2018 Sep 1;74(Pt 9):558-566. doi:, 10.1107/S2053230X18009809. Epub 2018 Aug 29. PMID:30198888<ref>PMID:30198888</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 5zur" style="background-color:#fffaf0;"></div>

==See Also==
*[[Ferritin 3D structures|Ferritin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Achromobacter sp. DH1f]]
[[Category: Large Structures]]
[[Category: Ahmed M]]
[[Category: Ashraf A]]
[[Category: Biswal BK]]
[[Category: Dwivedy A]]
[[Category: Jha B]]
[[Category: Kumar D]]
[[Category: Singh KH]]