View source for 5zuz


==Solution Structure of the DNA-Binding Domain of Rok==
<StructureSection load='5zuz' size='340' side='right'caption='[[5zuz]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5zuz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZUZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zuz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zuz OCA], [https://pdbe.org/5zuz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zuz RCSB], [https://www.ebi.ac.uk/pdbsum/5zuz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zuz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ROK_BACSU ROK_BACSU] Repressor of comK, the master regulator of competence development (PubMed:11849533). Overexpression seems to be lethal (PubMed:11849533). Represses at least 20 genes that specify membrane-localized and secreted proteins, including some that encode products with antibiotic activity (PubMed:15743949). Binds to many AT-rich sites in the chromosome, many of which are known or thought to derive from horizontal gene transfer; helps keep mobile element ICEBs1 quiescent in the genome (PubMed:21085634). Binds to its own promoter and is thus probably autoregulatory (PubMed:21085634).<ref>PMID:11849533</ref> <ref>PMID:15743949</ref> <ref>PMID:21085634</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Bacillus subtilis subsp. subtilis str. 168]]
[[Category: Large Structures]]
[[Category: Duan B]]
[[Category: Xia B]]