View source for 5zyi


==Crystal structure of CERT START domain in complex with compound E16==
<StructureSection load='5zyi' size='340' side='right'caption='[[5zyi]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5zyi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZYI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9ML:2-[4-[4-pentyl-3-[(1~{S},2~{R})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol'>9ML</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zyi OCA], [https://pdbe.org/5zyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zyi RCSB], [https://www.ebi.ac.uk/pdbsum/5zyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zyi ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/CERT_HUMAN CERT_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/CERT_HUMAN CERT_HUMAN] Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.<ref>PMID:14685229</ref> <ref>PMID:17591919</ref> <ref>PMID:18184806</ref> <ref>PMID:20036255</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Egawa D]]
[[Category: Hanada K]]
[[Category: Hanzawa H]]
[[Category: Kawasaki S]]
[[Category: Kobayashi S]]
[[Category: Kumagai K]]
[[Category: Nakao N]]
[[Category: Sakai S]]
[[Category: Suzuki M]]
[[Category: Ueno M]]