View source for 6a2r


==Mycobacterium tuberculosis LexA C-domain II==
<StructureSection load='6a2r' size='340' side='right'caption='[[6a2r]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6a2r]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6A2R FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6a2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a2r OCA], [https://pdbe.org/6a2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6a2r RCSB], [https://www.ebi.ac.uk/pdbsum/6a2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6a2r ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LEXA_MYCTU LEXA_MYCTU] Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Has been shown to bind to the 14 bp palindromic sequence 5'-CGAACNNNNGTTCG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Chandran AV]]
[[Category: Paul A]]
[[Category: Srikalaivani R]]
[[Category: Vijayan M]]